Plasticity changes in the ACC play a crucial role in emotional disorders associated with chronic pain.[47, 48] Specifically, NMDA receptor‐dependent long‐term potentiation (LTP) in the ACC sustains the affective dimensions of chronic pain.[49] Blocking presynaptic LTP in the ACC with oxytocin can alleviate the anxiety caused by chronic pain.[50] These indicate that plastic changes in the synapses of ACC neurons are of great significance in emotional disorders accompanied by chronic pain. Here, OXT is linked to Anxiety.