Moreover, upregulation of DNase expression following O. splanchnicus intervention suggested a potential contribution to NETs clearance, although further studies are needed to confirm its specific role in extracellular DNA degradation.[40] Collectively, these results supported a model in which O. splanchnicus modulates neutrophil function and PAD4‐dependent NETosis to maintain mucosal integrity during colitis. The gene discussed is PADI4; the disease is colitis.