STX17 and metabolic dysfunction-associated steatotic liver disease: Previous research has demonstrated that progressive increases in hepatic protein homocysteinylation and ubiquitination of STX17 are associated with autophagy blockade and subsequent fibrosis in nonalcoholic fatty liver disease.[13] Consistent with these findings, our results revealed that elevated Hcy levels enhanced homocysteinylation and ubiquitination of STX17.