In addition, fold change in ROS production was markedly increased in the heterozygous C1858T PTPN22 (n = 10) vs. wild-type C1858C PTPN22 (n = 6) T1D patients (p < 0.05) (Figure 3C); although a broader comparison among all genotypes (HD, WT, and HET) revealed a similar trend, the differences were not statistically significant (Supplementary Figure 3). This evidence concerns the gene PTPN22 and type 1 diabetes mellitus.