Lyn, a member of the Src family kinases (SFKs), can reduce the levels of inflammatory mediators by inhibiting the phosphorylation of signal transducer and activator of transcription 3 (STAT3) and apoptosis, exerting a protective effect on renal tubular injury in SA-AKI mice (Thomas and Brugge, 1997; Wang et al., 2017; Schreiner et al., 2002) (Figure 2). Here, STAT3 is linked to acute kidney injury.