IRF3 and acute kidney injury: Research has revealed that the Cytosolic mtDNA-cGAS-STING signaling axis can activate the LRP3 inflammasome by promoting the phosphorylation of STIG, TANK-binding kinase 1 (TBK1), and interferon regulatory factor 3 (IRF3), thereby exerting a proinflammatory effect in SA-AKI.