Resveratrol, a known SIRT1 activator, effectively restore the activity of SIRT1/3 in sepsis rats with AKI, reduce the acetylation levels of recombinant superoxide dismutase 2 (SOD2), improve oxidative stress and mitochondrial function in renal tubular epithelial cells, and extend survival time (Xu et al., 2016). The gene discussed is SIRT1; the disease is Sepsis.