Renal tissue fibrosis is a significant hallmark of CKD, and an animal study has revealed that Dex mitigates LPS or transforming growth factor-beta 1 (TGF-β1)-induced epithelial-to-mesenchymal transition (EMT), while also preventing necrosis, necroptotic apoptosis, and pyroptosis in HK-2 cells responding to LPS stimulation (Sun Q. et al., 2024). The gene discussed is TGFB1; the disease is chronic kidney disease.