STAT3 and acute myeloid leukemia: Zhang PP. et al. (2022) found that matrine inhibited cell proliferation and inflammatory cytokine levels, induced apoptosis, and downregulated the expression of LINC01116 while upregulating miR-592. In vivo studies showed that matrine suppressed tumor growth by regulating the LINC01116/miR-592 axis and inactivated the JAK/STAT3 signaling pathway in AML cells through this axis.