Cui et al. demonstrated that SAL intervention in PD models increased Lactobacillus abundance while reducing Aerococcus, Desulfovibrio, and Staphylococcus; modulated TAU-associated metabolic pathways; enhanced intestinal length and structural integrity; downregulated IL-6, IL-1β, and TNF-α expression; inhibited α-syn deposition and glial activation; and ameliorated motor dysfunction and neuronal loss (Cui, 2022). This evidence concerns the gene TNF and Parkinson disease.