Cordycepin, a nucleoside compound derived from the medicinal fungus Cordyceps sinensis, demonstrates significant therapeutic potential against neuroinflammation in PD by targeting multiple pathways, including NLRP3 inflammasome and TLR/NF-κB signaling (Cheng and Zhu, 2019; Zhang et al., 2021; Sharma et al., 2023). Here, NFKB1 is linked to Parkinson disease.