Here, we showed that MSC-Exos markedly inhibit the NF-κB pathway in Tfh, consistent with a recent evidence showing the anti-inflammatory effects of bone marrow-derived MSCs derived exosomes (BMSC-Exos) through NF-κB down-regulation to reduce intervertebral disc degeneration [44]. Here, NFKB1 is linked to Intervertebral disk degeneration.