SGHS is observed regardless of the presence of non-renal factors that may influence cystatin C and creatinine concentrations, such as creatinine's correlation with muscle mass and dietary protein intake from cooked meat, and cystatin C's correlation with fat mass, and its potential impact from glucocorticoid treatment and thyroid disorders [8, 10, 11]. This evidence concerns the gene CST3 and thyroid gland disorder.