In fact, a literature search of all features with a non-zero regression coefficient in the TEM 2-group model revealed that for 22 of 23 features, prior studies suggest an involvement of the respective genes or surface markers in the T cell immune response or lung cancer biology, respectively (Supplementary Table S12)—for instance, GIMAP4, a marker upregulated in non-responders, is known to accelerate T cell death (52). Here, GIMAP4 is linked to lung cancer.