The biosynthesis of organophosphates mediated by proteins such as INPP4A and PNPO suggests that the active phospholipid metabolism and membrane dynamics regulation in LNRg samples are enriched through folate metabolism mediated by proteins such as DHFR, indicating a possible increase in the demand for nucleic acid synthesis, consistent with the characteristics of rapidly proliferating tumor cells (38). The gene discussed is DHFR; the disease is neoplasm.