PDGFRB and neoplasm with perivascular epithelioid cell differentiation: Small molecule tyrosinase inhibitors such as Sorafenib, Sunitinib and Pazopanib are multi-targeted inhibitors that exert anti-angiogenic effects by inhibiting VEGFR, PDGFR and other pathways, and have achieved partial remission in several PEComa patients (22, 23).