Insulin-mediated activation of HIF1 signaling highlights its role in promoting cancer cell survival, proliferation, and adaptation to the anti-tumor microenvironments, highlighting the complex interplay between metabolic processes and cancer progression (Figure 2) (11) In the case of insulin resistance, it is important to note that different types of insulin-activated, signaling pathways identify an important critical distinction. This evidence concerns the gene INS and neoplasm.