Research indicated that curcumin can augment the quantities of cluster of differentiation 4-positive (CD4+) T cells, cluster of differentiation 8-positive (CD8+) T cells, and IFN-γ within the TME, thereby enhancing their immune cytotoxic capabilities against tumor cells, while concurrently reducing cluster of differentiation 25 (CD25), regulatory T cells, and inflammatory cytokine levels, bolstering immune responsiveness and restoring immune surveillance capacity [24]. Here, IFNG is linked to neoplasm.