DNA nanostructures incorporated into microneedles capable of delivering IL‐17A siRNA into psoriatic lesions were fabricated that showed a great promise in treating psoriasis by dampening ROS levels [23]. Additionally, combined use of monomethyl fumarate and aluminum ions showed a superior efficacy in treating psoriasis in vivo via modulating the NRF2/NFκB pathway toward diminished oxidative stress [169]. The gene discussed is NFKB1; the disease is psoriasis.