Studies have shown that promoter-driven gene therapy, such as Myo15 promoter-mediated hair cell-specific gene therapy, holds potential clinical applications for various forms of hearing impairment, including autosomal recessive deafness (Wang et al., 2024a), thus underscoring the importance of promoters as therapeutic targets in hearing loss research (Aaron et al., 2023). The gene discussed is MYO15A; the disease is deafness.