Based on the levels of 10 HGRMDEGs (ALDOB, ALDOC, AQP1, CCNA2, IL1A, JUND, NDRG1, PHGDH, PTGIS, VEGFA) in cancer samples in the TCGA-COADREAD dataset, we first investigated the correlation between them using the Spearman algorithm and presented the results in the form of correlation heatmaps (Figure 8a) and correlation chord plots (Figure 8b). This evidence concerns the gene IL1A and cancer.