In contrast, neuropeptide Y (NPY) contributes to obesity-related OSAS through its involvement in appetite stimulation, fat accumulation via hypothalamic pathways [3, 9] and amplification of hypoxic stress via peptidylglycine α-amidating monooxygenase (PAM)–mediated upregulation during intermittent hypoxia [10]. The gene discussed is NPY; the disease is Obesity.