DDIT3 and type 2 diabetes mellitus: In a T2D mouse model, delivery of constitutively active PI3K (p110α) via recombinant adeno-associated virus rAAV6-caPI3K significantly improved left ventricular function, as evidenced by increased LVEF and LVFS, and downregulated ERS-related markers GRP94 and CHOP, suggesting that PI3K is a potential therapeutic target for DMCM (125).