DSG2 and Arrhythmogenic right ventricular dysplasia: Desmoglein-2 (DSG2) pathogenic variants—the second most frequent genetic cause of ARVC, accounting for ∼10% of cases—cause characteristic pathological changes in human and murine hearts, including cardiomyocyte necrosis, immune infiltration, biventricular fibrofatty replacement, and desmosomal abnormalities.