Fc gamma receptor (FcγR) engagement polarizes macrophages toward M1 phenotypes [inducible nitric oxide synthase (iNOS)/reactive oxygen species (ROS) production] that enhance tumor killing and T-cell infiltration [56, 57], while IL-1β/TNF-α suppress IL-4/IL-13-driven M2 polarization [58, 59]. Here, NOS2 is linked to neoplasm.