Alterations in plasma enzyme lecithin acyltransferase (LCAT), reduction in the biosynthesis of PL in liver diseases, alteration in the transformation of PL from plasma to the erythrocytes, enhanced bile salt concentrations in liver disorders, and inability to synthesize PLs for regenerating hepatocytes have been associated with changes in red blood cell PLs composition. The gene discussed is LCAT; the disease is liver disorder.