In 64 kinds of immune cells, there are 26 kinds of cell types in the significant differences between VD group and control group (P < 0.001 ∼ “* * *,” P < 0.01 ∼ “* *,” P < 0.05 ∼ “*”) (Figure 4A), and in VD group, aDC, Adipocytes, B cells, CD4+ memory T-cells, CD4+ Tem, CD8+ Tem, Macrophages, Macrophages M1, Mast cells, Monocytes, MPP, Preadipocytes, Skeletal muscle, Tgd cells, Tregs increased expression, immune cell expression of CLP, GMP, HSC, Keratinocytes, Megakaryocytes, Melanocytes, MSC, Neurons, NKT, Osteoblast, Sebocytes were reduced (Figure 4B). This evidence concerns the gene CD4 and sexually transmitted disease.