Experimental evidence indicates that in mouse models of acute ischemic stroke, ANGPTL4 promotes angiogenesis and neurogenesis (Qiu et al., 2021; Spescha et al., 2013; Bouleti et al., 2013), thereby facilitating the recovery of neurological function and cognitive impairment at the earliest possible stage. The gene discussed is ANGPTL4; the disease is Cognitive impairment.