Insulin sensitivity and production are improved by vitamin D through the regulation of glucose metabolism via vitamin D receptors (VDRs) in adipocytes, myocytes, and insulin-producing β-cells [1,8-10].. Recent evidence further confirms these mechanisms, demonstrating that vitamin D supplementation upregulates insulin receptor expression and reduces systemic inflammation in T2DM patients [11]. Here, INS is linked to type 2 diabetes mellitus.