Calcium is another micronutrient, essential for the regulation of insulin-mediated intracellular signaling pathways as well as the release of insulin by pancreatic β-cells. While maintaining appropriate intracellular calcium concentrations is essential for appropriate insulin signal transduction and metabolic function, research shows that hypocalcemia can disturb glucose homeostasis by affecting insulin release [9]. This evidence concerns the gene INS and Hypocalcemia.