Colonoscopic screening and the removal of adenomas have been reported to reduce the risk of CRC development and decrease overall mortality by about 65% in LS families (50); therefore, preventative surveillance in asymptomatic patients using colonoscopy is recommended every 2 years in the UK, starting at the age of 25 years for MLH1 or MSH2 pathogenic gene carriers or 35 years for MSH6 or PMS2 carriers (47). This evidence concerns the gene PMS2 and colorectal carcinoma.