MSH6 and colorectal carcinoma: Colonoscopic screening and the removal of adenomas have been reported to reduce the risk of CRC development and decrease overall mortality by about 65% in LS families (50); therefore, preventative surveillance in asymptomatic patients using colonoscopy is recommended every 2 years in the UK, starting at the age of 25 years for MLH1 or MSH2 pathogenic gene carriers or 35 years for MSH6 or PMS2 carriers (47).