TGFB1 and idiopathic pulmonary fibrosis: Notably, NFIB expression is markedly reduced in IPF patients and BLM-treated mice; miR-326 targets the 3′-UTR of NFIB, restores its expression, and NFIB up-regulation suppresses TGF-β signaling, lowers collagen deposition and mesenchymal markers, thereby reversing fibrotic pathology (111).