THBS1 and neoplasm: CD47 is associated with VEGFR, which is another proximal lateral binding partner, in endothelial cells (3); however, THBS1 induces disassociation of this complex and inhibits VEGFR2 signaling through CD47 to indirectly regulate tumor growth (13), beside we infer that CD47 inhibits THBS1, while inactivated THBS1 can inhibit an important signaling pathway: inhibition of angiogenesis by THBS1 signaling pathway, thereby activating angiogenesis (Figure 4B), and we will further confirm in the future.