COMT and Parkinson disease: We analyzed COMT variants in 2251 PD patients and 2835 controls of European descent using whole‐genome sequencing from the Accelerating Medicines Partnership‐Parkinson Disease (AMP‐PD), along with 20,427 PD patients and 11,837 controls from 10 ancestries using genotyping data from the Global Parkinson's Genetics Program (GP2).