SPI1 and open-angle glaucoma: Given the close connection between glaucoma and brain function, our study focused on the relationship and similarities between AD and POAG.[39,40] Previous studies have identified several shared genetic loci and protein-coding genes, such as MTCH2, NDUFS3, SPI1, MYBPC3, and PTPMT1, suggesting common genetic markers between the 2 conditions.[41] In our study, we identified 18 overlapping DEGs between AD and POAG.