Under stress, downregulation of VE-cadherin, β-catenin, VEGFR-1, VEGFR-2, vimentin, Cdc42, and ACK1 was observed in the retina.[49] In AD mouse model, tight junctions in the intestine can be disrupted by Aβ deposition.[50] For example, Aβ and Tau protein deposits in the retina and central visual systems of experimental high IOP model.[51]. Here, CDH5 is linked to Alzheimer disease.