Dysregulation of FZD1 has been linked to neurodegenerative processes in AD.[43] Given its involvement in retinal development, our study suggested that FZD1 dysregulation may contribute to RGCs damage in glaucoma.[44] EFNA1, which is essential for axon guidance and neuronal communication, also plays a key role in synaptic plasticity.[45] The activation of EFNA1 may therefore promote neuronal regeneration, offering potential therapeutic insights for neurodegenerative diseases.[46] LTBP3 regulates the activation of TGF-β, a cytokine involved in tissue repair and fibrosis. The gene discussed is FZD1; the disease is neurodegenerative disease.