There were also significant differences in metabolic markers, with those with gallstones presenting higher fasting glucose levels (121.1 ± 42.0 vs 112.9 ± 37.3 mg/dL), a higher tyG index (8.7 ± 0.7 vs 8.5 ± 0.7), and higher CRP levels (2.8 vs 1.9 mg/dL) (all P < .001). This evidence concerns the gene CRP and gallstones.