MTOR and Cognitive impairment: Studies have found that acupuncture can alleviate inflammation-related cognitive impairment by inhibiting the nuclear factor-kappa B signaling pathway[12] and can also reverse the upregulation of inflammatory gene expression in VCI models, thereby improving the state of cognitive impairment.[13] Studies have also shown that acupuncture can effectively alleviate vascular cognitive dysfunction and reduce apoptosis, inflammation, and autophagy by regulating the autophagy–inflammation pathway mediated by mTOR/NLRP3.[14]