For example, a randomized trial found that a low-fat diet intervention significantly lowered CRP in women with metabolic syndrome, whereas men did not show as much benefit.[22] This suggests women’s diet-sensitive inflammation can be high when baseline risk (e.g. obesity, metabolic dysfunction) is present, but also that women might require more intensive or targeted interventions to overcome both behavioral and biological drivers of inflammation. Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.