CRP and obesity due to melanocortin 4 receptor deficiency: Farmer et al reported that in older men, behavioral factors (including diet and exercise) explained about 29% of the Black–White CRP disparity, whereas in older women the disparity was mostly attributable to non-behavioral physiological factors (~40% related to obesity, metabolic and hormonal differences).[12] Women generally have higher baseline inflammation than men, partly due to higher adiposity and hormonal influences,[19,20] which may not be fully mitigated by diet and exercise alone.