Despite these concerning findings, 3 days later (hospital day 25), her G-CSF dose was increased to 300 μg twice daily; this decision was primarily based on the persistently low neutrophil count (WBC count was 0.05 × 103/μL), but also because G-CSF had not yet been suspected as the cause of her isolated hyperbilirubinemia. Here, CSF3 is linked to Hyperbilirubinemia.