We observed significantly higher levels of NLR, ESR, and CRP in RA patients than in non-RA patients, suggesting that a more severe immune imbalance and inflammatory state may exist in RA patients, similar to the study by Jin et al.[39] After adjusting for confounders, our multifactorial logistic regression model showed that gender, age, NLR, ESR and CRP were independent predictors of RA. Here, ESR1 is linked to rheumatoid arthritis.