The results of the association rule analysis showed that the reduction in NLR levels was highly associated with remission of ESR, CRP, RF, PGA, CPRI-RA, SAS, and SDS, as well as a strong correlation with improvement in the levels of PF, BP, GH, VT, and MH, and that all associations had a support >40%, a confidence level >60%, and a gain >1 (Table S4, Supplemental Digital Content, https://links.lww.com/MD/Q66 and Fig. 10A). The gene discussed is ESR1; the disease is rheumatoid arthritis.