A total of 544 articles were retrieved, focusing on the pathophysiology and clinical studies of RA-NLR, such as “disease activity,” “inflammation” and “classification.” Retrospective analysis demonstrated that NLR, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels were significantly higher in RA patients than in non-RA patients. This evidence concerns the gene CRP and rheumatoid arthritis.