Risk factors for progression from stage 3 zone 2 despite VEGF inhibitors include, but are not limited to, gestational age of less than 29.5 weeks, the presence of posterior zone 1 disease, the occurrence of preretinal haemorrhages, history of sepsis, oxygen therapy, mechanical ventilation, respiratory distress syndrome, and patent ductus arteriosus [5, 6]. This evidence concerns the gene VEGFA and Sepsis.