In summary, while FUS::DDIT3 binding caused no extreme effects on the SWI/SNF composition, several paralogs as well as PBAF and GBAF subtype-specific components were significantly enriched in FUS::DDIT3-bound SWI/SNF complexes, at levels that may impact the SWI/SNF function in FET sarcoma cells. Here, SMARCA1 is linked to sarcoma.