While for high Ki-67 pattern identification, the optimal cutoff value was estimated to be greater than or equal to 2.98, 3.52, 6.52, 1.75, 2.21, 1.54, 2.05, 2.55 and 2.29 for tumor MeanLin ratio, tumor PE ratio, tumor WiPI ratio, margin MeanLin ratio, margin PE ratio, margin WiAUC ratio, margin WiR ratio, margin WiPI ratio, margin WoR ratio, respectively (Table S3). Here, MKI67 is linked to neoplasm.