NLRP3 and Hyperglycemia: Hyperglycemia triggers a retinal ROS burst through polyol pathway activation and accumulation of AGEs33, which in turn phosphorylates the Tyr97 site of NEK7 kinase and promotes the binding of NEK7 to the LRR structural domain of NLRP335,36, resulting in the formation of a stable NEK7-NLRP3 complex9.