There was also evidence (P < .05) for a causal effect of total testosterone on risk of endometrial cancer; IGF-1 and leptin on risk of luminal B/HER2-negative-like breast cancer; adiponectin on risk of triple-negative or basal-like breast cancer; total testosterone on risk of luminal B-like breast cancer; total testosterone on risk of endometrioid endometrial cancer; and SHBG on risk of non-endometrioid endometrial cancer (Figure 4, Table S12). This evidence concerns the gene ADIPOQ and breast carcinoma.