Note that conditional F-statistics were also <10 for multivariable MR analyses examining a potential mediating role of CXCL-8 in the effect of ASAT on ovarian cancer risk, and HDL cholesterol in the effect of ASAT on triple-negative or basal-like breast cancer risk, indicating possible underestimation of their mediating roles. The gene discussed is CXCL8; the disease is breast cancer.