ABCB7 and colorectal cancer: Furthermore, our analysis focused on adiposity distribution traits—such as ASAT, VAT, GFAT, liver fat, and pancreas fat—rather than total adiposity, and it is possible that the associations with cancer risk reported in previous studies are driven primarily by overall adiposity (as in the case of colorectal cancer, for which we did see evidence for a causal effect, consistent with previous studies,79,80 of higher genetically predicted BMI on risk).