We also found evidence for a mediating role of bioavailable testosterone in the effect of ASAT on risk of endometrial cancer (although this analysis may also suffer from weak instrument bias), IGFBP-1 in the effect of ASAT on esophageal adenocarcinoma, adiponectin in the effect of GFAT on non-endometrioid endometrial cancer, and fasting insulin and bioavailable testosterone in the effect of ASAT on risk of endometrial cancer. The gene discussed is ADIPOQ; the disease is endometrial cancer.