DAXX and carcinoma: Additionally, both variants involve chaperone network dysfunction, with specific chaperones playing roles in their oncogenic effects: CAF-1 overexpression (linked to H3.1) supports replication and proliferation in carcinomas, while dysregulation of DAXX/ATRX (linked to H3.3) through mutations, loss or overexpression disrupts H3.3 deposition, chromatin integrity and gene regulation, as seen in interactions like DAXX-TCF4 affecting cyclin D1.