ORMDL3 and asthma: ORMDL3 activates the ATF6α pathway within the unfolded protein response (UPR), upregulates SERCA2b expression, and subsequently induces the production of multiple pro-inflammatory and pro-remodelling factors in human bronchial epithelial cells, thereby directly linking endoplasmic reticulum stress to the process of airway remodelling in asthma.92