The analysis indicated that the genes MAFA, CLU, RHOB, RASD1, HSPA1B, HSPA1A, HMOX1, CXCL8, DNAJB1, NCF2, SAT1, IER5, BAG3, B4GALNT1, CCL3, ANXA2, PPP1R15A, CES1, and JUN, which were induced in EF-24–treated cells (Fig 5B), may participate in cancer progression [17,21–23]. The gene discussed is CES1; the disease is cancer.