Deeper interrogation of this cluster also highlighted previously unidentified type I IFN−dependent genes in TB-susceptible C3HeB/FeJ mice, including Il36g, encoding IL-36γ, a cytokine implicated in mucosal inflammatory responses (Yuan et al., 2019), and Slfn4, encoding Schlafen 4 (Fig. 10, b and c), previously identified as a marker of myeloid cells with immune-suppressive function in a gastric metaplasia model (Ding et al., 2016). Here, IL36G is linked to tuberculosis.