Consistent with an association of these genes with progression toward severe TB, we observed a more pronounced increase in Il36g and Slfn4 expression in lungs of C3HeB/FeJ compared with C57BL/6 mice at 21 days after infection, and Slfn4 expression was most highly enriched in the disease-associated, pro-inflammatory neutrophil 2 scRNA-seq cluster (Fig. S5, h and i). Here, IL36G is linked to infection.