IFNG and infection: Thus, our initial scRNA-seq analysis showed that the enhanced early immune response to M. tuberculosis in relatively TB-resistant C57BL/6 mice is distinguished by accumulation of mature/activated MDMs and IFN-γ–producing effector T cells, with limited progression of the pro-inflammatory neutrophil response, while neutrophil activation is exacerbated as infection progresses in C3HeB/FeJ mice.