This is in contrast to the recently reported TB susceptibility phenotype in C57BL/6 mice carrying a deletion in the IFN-γ–inducible GTPase gene Irgm1 (Rai et al., 2023), which display impaired CD4+ T cell response initiation dependent on excessive type I IFN production (Naik et al., 2024). The gene discussed is IRGM; the disease is tuberculosis.