Moreover, the deletion of METTL3 or METTL14 increases the infiltration of cytotoxic CD8+ T cells and the secretion of the cytokines IFN-γ, CXCL9, and CXCL10, thereby improving the response to anti-PD-1 therapy in colorectal cancer [230]. Here, METTL3 is linked to colorectal cancer.