GPX4 and colorectal cancer: Moreover, FTO overexpression upregulates solute carrier family 7 member 11 (SLC7A11) and glutathione peroxidase 4 (GPX4) expression through m6A-YTHDF2-dependent mechanisms, thereby suppressing ferroptosis, while FTO inhibition induces ferroptosis in colorectal cancer cells via downregulation of these anti-ferroptotic factors [77].