In addition, ALKBH5 posttranscriptionally activates period circadian regulator 1 (PER1) in an m6A-YTHDF2-dependent mechanism, with subsequent PER1 upregulation driving reactivation of the ATM–CHK2–CDC25C signaling cascade to suppress pancreatic cancer cell proliferation [80]. Here, ALKBH5 is linked to familial pancreatic carcinoma.