In colon cancer, SH3GL3 expression increases in higher-grade tumors, and EndoA3 supports two pro-tumoral mechanisms: (i) cytosolic EndoA3 binds to the GEF Tiam1, activating Rac1 and subsequent cell migration, and (ii) membrane-associated EndoA3 promotes proliferation via its endocytic activity [214]. The gene discussed is SH3GL3; the disease is colonic neoplasm.