Several tumor histotypes, including sarcomas, express NK/CIK activating ligands, among which the NKG2D ligands (NKG2DLs), such as the stress-inducible ligands MHC class I chain-related protein A and B (MICA/B) and the UL16 binding proteins (ULBP2/3/5/6) [30–32]. This evidence concerns the gene MICA and sarcoma.