CD40LG and atherosclerosis: MZ and B1 cells on the other hand help prevent atherosclerosis development by producing large quantities of natural IgM antibodies directed towards oxidation-specific epitopes present on apoptotic cells and modified lipids[11, 90] Natural IgM from B-1/MZ B cells targets oxidation-specific epitopes (e.g., phosphorylcholine on oxLDL), opsonizes apoptotic bodies, limits foam-cell formation, and reduces necrotic cores; adoptive transfer and loss-of-function studies demonstrate causal protection (Fig. 3) [68, 69].