2017). This integrin was recently implicated in the binding and uptake of cancer‐derived exosomes (Cardeñes et al. 2021; De Jong et al. 2020). Our analyses by flow cytometry confirmed reduced plasma membrane expression of α5β1 but also other integrin heterodimers (α2β1, α3β1) as well as ALCAM in COMMD5 KO HeLa cells (Figure 6A). Here, COMMD5 is linked to cancer.