What is noteworthy is that either MK2206, PD0325901, or Stattic treatment could partly block FXR-induced HVEM upregulation, suggesting another mechanism that FXR-induced HVEM is partly mediated by the intracellular Akt, Erk1/2, and STAT3 signals in NSCLC. Here, STAT3 is linked to non-small cell lung carcinoma.