NF2 and neoplasm: Neurofibromin 2 (Nf2), encoding a protein called Merlin, a well-characterized tumor suppressor (31–33), undergoes dynamic phosphorylation-dependent regulation (e.g., Ser10, Thr230, Ser315, Ser518) by kinases such as PKA (34–36), PI3K/AKT (37), and p21-activated kinase (PAK) (38) to control cell proliferation and morphogenesis.