MAP2K7 and glioblastoma: Differential gene expression and GSEA comparing selumetinib-treated and vehicle-treated conditions across nontumor cell clusters revealed selumetinib treatment was associated with an interferon-mediated inflammatory response in microglia (C4), endothelial cells (C7), and oligodendrocytes (C8), suggesting MEK inhibition may have a pro-inflammatory effect on the glioblastoma tumor microenvironment (Supplemental Figure 11I).