To define the genetic landscape of NF1-mutant, IDH wild-type glioblastoma, we retrospectively identified 186 newly diagnosed glioblastomas that underwent targeted DNA sequencing and harbored a somatic NF1 mutation (Supplemental Table 1; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.192658DS1). Here, NF1 is linked to glioblastoma.