TP53 and glioblastoma: By integrating genes required for growth in both screens, a 31-gene consensus cell cycle signature required for NF1-mutant glioblastoma cell growth was identified that was enriched for components within the cyclin-dependent kinase (CDK), retinoblastoma, or TP53 pathways (Supplemental Figure 14E), consistent with comutations in cell cycle regulatory genes, such as CDKN2A/B observed in human tumors (Figure 1A), further serving as a technical validation of our screen in identifying cell cycle genes required for tumor cell growth.