Prior work has demonstrated NF1-mutant glioblastomas are enriched for MES-like transcriptional signatures compared with NF1 wild-type glioblastomas, but how the cellular composition varies across NF1-mutant glioblastomas and the dominant signaling mechanisms and potential druggable dependencies within the MES-like versus non-MES compartments remain unclear. Here, NF1 is linked to glioblastoma.